1975 Volume 23 Issue 6 Pages 1377-1380
The antibacterial activities of sulfadimethoxine in rabbit plasma were significantly increased by concomitant injection of phenylbutazone. On the other hand, the levels of unchanged sulfadimethoxine determined by chemical assay in rabbit plasma were significantly reduced by concomitant injection of phenylbutazone. These results suggest that phenylbutazone increases the transfer of sulfadimethoxine from plasma to tissues in rabbits.