Enzyme Activities of Liver Plasma Membrane in Rat Bile after the Intrabiliary Retrograde Infusion of Triton X-100

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The activities of three bile canalicular enzymes, alkaline phosphatase, 5'-nucleotidase and ATPase, and protein concentration in bile were significantly elevated by the intrabiliary retrograde infusion of Triton X-100. The results suggest that a part of the bile canalicular site of the liver plasma membrane was solubilized by the treatment. This explains the fact that the active biliary excretion of organic anions and cations was markedly inhibited by the same treatment.