Human Chorionic Gonadotropin. IV. Synthesis of a Hexadecapeptide corresponding to the C-Terminal Sequence 130-145 of the β-Subunit of Human Chorionic Gonadotropin (hCG)

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The hexadecapeptide corresponding to sequence 130-145 of the β-subunit of human chorionic gonadotropin (hCG) according to the amino acid sequence proposed by Morgan et al. was synthesized by successive azide condensation of 4 peptide fragments, followed by TFA treatment and catalytic hydrogenation. This peptide was conjugated with bovine serum albumin (BSA). Antiserum produced against this conjugate did not bind with ¹²⁵I-hCG.