Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Mixing of Pharmaceutical Powders and Granules. II. Mixing Degree of Granules and Various Kinds of Powders
HIROSHI FUJIWARASUSUMU KAWASHIMASACHIKO OMURA
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1982 Volume 30 Issue 2 Pages 666-672

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Abstract
The mixing degree between granules and various kinds of powders was investigated based on the assumption that it could be treated similarly to the pure granule system described in the previous paper. The theoretical mixing degree of the target particles for complete mixing was determined by assuming that it could be calculated from the arbitrary content of each particle and the grain size distribution. Experimental values of mixing degree obtained by using various kinds of powders, such as talc, synthetic aluminium silicate, magnesium oxide and lactose, and granules were in good agreement with the theoretical results. These theoretical mixing degrees may be useful as an indication of the limits of practical mixing of powders and granules.
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© The Pharmaceutical Society of Japan
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