Abstract
Dissolution profiles of indomethacin (IMC) dispersed in water-soluble polymers were investigated by the rotating disk method, and large differences in dissolution behavior were observed with different kinds of polymers. Therefore, the physico-chemical nature of the polymers might play a predominant role in the dissolution of IMC from these systems. The quantitative relationship of dissolution behavior with several properties of the polymers was investigated by the application of multiple regression analysis. A reasonably good fit, with statistical significance, between experimental and calculated values in the initial dissolution stage was obtained by taking into account factors such as water penetration of the compressed disk surface, hardness and gelation of polymers.
