AGONIST-ANTAGONIST PROPERTIES OF 5, 7-ETHANO-4, 5, 5a, 6, 7, 11b-HEXAHYDRO-2, 6, 7-TRIMETHYL-1H-BENZO [g] HOMOQUINOLIN-9-OL AND 4, 6-ETHANO-3, 4, 4a, 5, 6, 10b-HEXAHYDRO-2, 5, 6-TRIMETHYLBENZO [f] QUINOLIN-8-OL

Mikio Hori; Tadashi Kataoka; Hiroshi Shimizu; Eiji Imai; Yoshinari Suzuki; Norihiro Kawamura; Hajime Fujimura; Masakatsu Nozaki; Masayuki Niwa

doi:10.1248/cpb.31.2520

Mikio Hori, Tadashi Kataoka, Hiroshi Shimizu, Eiji Imai, Yoshinari Suzuki, Norihiro Kawamura, Hajime Fujimura, Masakatsu Nozaki, Masayuki Niwa

Author information

Keywords: stracture activity relationship

JOURNAL FREE ACCESS

1983 Volume 31 Issue 7 Pages 2520-2522

DOI https://doi.org/10.1248/cpb.31.2520

Details

Abstract

Agonistic and antagonistic properties of novel tetracyclic benzomorphans (1-4) were evaluated in vivo and in vitro opioid receptor interaction tests. Seven-membered derivatives (1, 3) showed synergism with morphine analgesia. Six-membered derivatives (2, 4) demonstrated antagonist opioid characters.

Corresponding author

Register with J-STAGE for free!