抄録
3-Formylrifamycin S (9) was found to react with secondary aliphatic amines to give 2, 3-dihydropyrimido [4, 5-b] rifamycin derivatives 4, in which the 2'-position was substituted with an alkyl group. When 7-, 8-, and 9-membered alicyclic amines were used, 2, 3-dihydropyrimido [4, 5-b] rifamycin derivatives 5, in which the 1'-and 2'-position were linked with a methylene chain, were obtained. The configuration of the 2'-position in 4 and 5 is discussed. The mechanism of formation of 4 and 5 is also discussed.
