Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
The Biologically Active Constituents of Ganoderma lucidum (FR.) KARST. Histamine Release-Inhibitory Triterpenes
HIROSHI KOHDAWAKAKO TOKUMOTOKIYOE SAKAMOTOMICHIKO FUJIIYUKO HIRAIKAZUO YAMASAKIYASUO KOMODAHIDEO NAKAMURASHIGEMASA ISHIHARAMASARU UCHIDA
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Keywords: histamine release
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1985 Volume 33 Issue 4 Pages 1367-1374

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Abstract

The MeOH extract of Ganoderma lucidum has an inhibitory action on histamine release from rat mast cells. From the physiologically active fraction of the extract, along with the known triterpenes ganoderic acids A and B, two new triterpenes were isolated and named ganoderic acids C and D. The structures of ganoderic acids C and D were determined to be 3β, 7β, 15α-trihydroxy-11, 23-dioxo-5α-lanost-8-en-26-oic acid and 7β-hydroxy-3, 11, 15, 23-tetraoxo-5α-lanost-8-en-26-oic acid respectively. Ganoderic acids C and D were shown to inhibit histamine release from rat mast cells. Quantitative analysis of these triterpenes was performed for the purpose of crude drug quality control.

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© The Pharmaceutical Society of Japan
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