Antitumor Activity of Pt(II) Complexes Containing Diaminocarboxylates and Their Ester Derivatives

Abstract

Antitumor Pt(II) complexes containing ester derivatives of DL-2, 3-diaminopropionate and DL-2, 4-diaminobutyrate were synthesized and their structures were determined from their infrared and ultraviolet absorption spectral data. The antitumor activity of these Pt(II) complexes was tested in vivo against leukemia L1210 according to the NCI Pt Analog Protocol. [Pt(Malonato)(DL-2, 3-diaminopropionate ethyl ester)] exhibited the highest antitumor effect with a T/C% value of 364 at an administration dose of 100 mg.The partition coefficients between water and n-octanol were measured, but no clear correlation with antitumor effects was found.