Studies on the Oxidation of 5H-N-Substituted Dibenz[b, f]azepines. III. : Oxidative Metabolism by Rat Liver Microsomes

Abstract

The metabolism of various 5H-N-substituted dibenz[b, f]azepines (1a-e) by rat liver microsomal fractions was investigated. 5H-N-Acyldibenz[b, f]azepines (1a-c) were metabolized to 5H-N-acyldibenz[b, f]azepine 10, 11-oxides (2a-c), while 5H-N-alkykibenz[b, f]azepines (1d, e) were metabolized to N-alkyl-9(10H)-acridones (5d, e). 5H-N-Acyl-10, 11-dihydro-trans-10, 11-dihydroxydibenz[b, f]azepine (3b) was additonally detected as a metabolite of 5H-N-acyldibens[b, f]azepine 10, 11-oxide (2b).The conditions for the enzymatic formation of these metabolites are discussed.