1986 Volume 34 Issue 9 Pages 3854-3860
In order to identify the active principles in the 50% MeOH extract of the Chinese crude drug "Chang Zhu" (consisting of Atractylodes lancea rhizome), which has a preventive activity against experimental ulcerations, the effects of the benzene, methanol and aqueous fractions from 50% MeOH extract on gastric secretion in pylorus-ligated rats were investigated.The terpenes, β-eudesmol and hinesol, contained in benzene fraction were found to be highly effective. β-Eudesmol markedly inhibited ulcers in Shay rats, as well as histamine- and aspirin-induced gastric ulcers, and showed anti-secretory activity on gastric acid secretion stimulated by histamine in a perfused rat stomach preparation.The anti-ulcerogenic activity of 50% MeOH extract of Atractylodes lancea rhizome might be mainly attributable to the H2-antagonistic effect of β-eudesmol.
