Technique of Measuring Rapid Water Penetration Rate into Tablets

Abstract

An accurate method for measuring the fast uptake of water into tablets was established. The method involved the use of a video camera to monitor the flow of liquid in the capillary tube of the water penetration apparatus. Measurements of water uptake could be made in as short an interval as 0.04 s from 0 s. The liquid penetration profiles show that there are three linear portions of the double logarithmic plot of volume penetrated vs. time, with a different slope for each linear portion.