AN EFFICIENT SYNTHESIS OF WF-3681, A NOVEL ALDOSE REDUCTASE INHIBITOR, AND ITS RELATED COMPOUNDS

Takayuki Namiki; Yasutaka Suzuki; Kozo Sawada; Yoshikuni Itoh; Teruo Oku; Yoshihiko Kitaura; Masashi Hashimoto

doi:10.1248/cpb.35.2594

Takayuki Namiki, Yasutaka Suzuki, Kozo Sawada, Yoshikuni Itoh, Teruo Oku, Yoshihiko Kitaura, Masashi Hashimoto

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Keywords: fungal metabolite, aldose reductase inhibitor, aldol condensation, phenylpyruvate, ω-formylalkanoate

JOURNAL FREE ACCESS

1987 Volume 35 Issue 6 Pages 2594-2597

DOI https://doi.org/10.1248/cpb.35.2594

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Abstract

WF-3681 (1a), an aldose reductase inhibitor, and its related compounds (1b-1j) have been synthesized by aldol condensation of phenylpyruvates and ω-formylalkanoates as a key step.

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