Synthesis and Effect on Gastric Secretion of Several Di-or Tripeptides Related to Proglumide

KOJI IUCHI; MASAHIRO NITTA; KEIZO ITO; KOICHI SHIMOHARA; GORO TSUKAMOT

doi:10.1248/cpb.36.3961

KOJI IUCHI, MASAHIRO NITTA, KEIZO ITO, KOICHI SHIMOHARA, GORO TSUKAMOT

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Keywords: proglumide, N-acyl-γ-L-glutamyl peptide, γ-glutamylphenylalanine amide, peptide synthesis, anti-gastric secretion

JOURNAL FREE ACCESS

1988 Volume 36 Issue 10 Pages 3961-3966

DOI https://doi.org/10.1248/cpb.36.3961

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Abstract

Several N-acyl di-or tripeptides related to proglumide (PhCO-DL-Glu-NPr₂) were prepared and their effects on gastric secretion were examined by intraperitoneal injection in rats. PhCOGlu (Phe-NH₂)-NPr₂, Z-Glu (Phe-NH₂)-NPr₂, PhCO-Glu (NPr₂)-Phe-NH₂ and PhCO-Asp-(Phe-NH₂)-NPr₂ inhibited gastric secretion, while PhCO-Glu (Asp-Phe-NH₂)-NPr₂ stimulated gastric secretion. Of these peptides, PhCO-Glu (Phe-NH₂)-NPr₂ showed the most potent inhibitory activity against gastric secretion, and was more potent than proglumide.

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