Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Anti-inflammatory Constituents of Topically Applied Crude Drugs. II. Constituents and Anti-inflammatory Effect of Cryptomeria japonica D. DON
MINEO SHIMIZU, HIDEKI TSUJI, HISASHI SHOGAWA, HIDEKI FUKUMURA, SEIICHI TANAAMI, TOSHIMITSU HAYASHI, MUNEHISA ARISAWA, NAOKATA MORITA
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Keywords: Cryptomeria japonica, Taxodiaceae, cis-communic acid, methyl (E)-13-hydroxylabda-8 (17), 11, 14-trien-19-oate, imbricataloic acid dimethyl acetal, anti-inflammatory effect, carrageenan edema, histamine-induced contraction
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1988 Volume 36 Issue 10 Pages 3967-3973

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Abstract

The ether-soluble fraction of MeOH extract from the leaves of Cryptomeria japonica D. DON showed an anti-inflammatory effect when topically applied to rats and an inhibitory effect on histamine-induced ileum contraction. The active component was isolated and identified as ciscommunic acid (1). Two new diterpenoids were also isolated along with two known compounds and were determined to be imbricataloic acid dimethyl acetal (5) and (E)-13-hydroxylabda-8 (17), 11, 14-trien-19-oic acid, obtained as the methyl ester (6m), by chemical and spectroscopic methods.

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© The Pharmaceutical Society of Japan
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