ffects of Solid Dispersion with Heptakis-(2, 6-di-O-methyl)-β-cyclodextrin on the Dissolution and Sublimation of Naphthalene

Abstract

The solid dispersion of naphthalene with heptakis-(2, 6-di-O-methyl)-β-cyclodextrin (DMCD) has been studied by using X-ray diffraction and thermal methods. The influence of the solid dispersion on the dissolution and sublimation of naphthalene were studied. X-Ray diffraction and thermal data indicated the amorphous state of naphthalene and DMCD. Enhanced dissolution and reduced sublimation characteristics were observed in the ground mixture and the coprecipitate. The sublimation rate of naphthalene from the ground mixture and the coprecipitate increased during storage at high relative humidity due to crystallization.