1988 Volume 36 Issue 10 Pages 4045-4054
Six solvates of griseofulvin with alkyl halide and, alkyl dihalides were isolated, and their crystallographic as well as physico-chemical properties were investigated by infrared spectroscopy, powder X-ray diffractometry, X-ray crystallographic analysis, thermogravimetry (TG) and differential scanning calorimetry (DSC). From the weight loss in TG curves, the combining ratios between the drug and the solvent were determined to be 1: 1 except for that of griseofulvin 1-bromo-2-chloroethane solvate (drug: solvent =1: 0.8). The cell dimensions of griseofulvin bromoethane solvate and griseofulvin dibromomethane solvate were almost equal, and the solvates formed a new type of mixed crystal (substitutional solid solution).
From X-ray crystallographic analysis, it was elucidated that the molecular arrangement in the dichloroethane solvate crystal was the same as that in the chloroform solvate determined by Shefteret al.
