Species Difference in the in Vitro Metabolic Reduction of Acetohexamide

Abstract

Species difference in the in vitro metabolic reduction of acetohexamide, an oral antidiabeticdrug, was investigated using the rabbit, guinea pig, hamster, rat and mouse. The rabbit exhibitedthe highest acetohexamide reductase activity in cytosol of the liver and kidney among the speciestested. The sensitivities to specific inhibitors of cytosolic acetohexamide reductase in the liver andkidney of the rabbit were different from those of the rat. Furthermore, species difference inacetohexamide reductase activity was found in the microsomes of the liver and kidney; only the rat and guinea pig showed significant activity.