Cytotoxicities of Autoxidized Polyunsaturated Fatty Acids toward Cultured Human Umbilical Vein Endothelial Cells

Abstract

Cytotoxicities of autoxidized polyunsaturated fatty acids toward human umbilical veinendothelial cells were examined. Autoxidized linoleic acid is more toxic than linoleic, autoxidizedlinolenic, or autoxidized arachidonic acid. Autoxidized linolenic acid is less toxic than linolenicacid. Autoxidized arachidonic acid is as toxic as linolenic or arachidonic acid. It was found thatmajor toxic components in autoxidized linoleic acid are linoleic acid hydroperoxides, and that a major component in autoxidized arachidonic acid is (E)-4-hydroxy-2-nonenal.