The Structural Elucidation of Fritillaria Alkaloids from Fritillaria ebeiensis var.purpurea. I. The Structures of Ebeienine, Ebeiedine and Ebeiedinone

PING LEE; YUKIE KITAMURA; KOH KANEKO; MOTOO SHIRO; GUO-JUN XU; YUH-PAN CHEN; HONG-YEN HSU

doi:10.1248/cpb.36.4316

The Structural Elucidation of Fritillaria Alkaloids from Fritillaria ebeiensis var.purpurea. I. The Structures of Ebeienine, Ebeiedine and Ebeiedinone

PING LEE, YUKIE KITAMURA, KOH KANEKO, MOTOO SHIRO, GUO-JUN XU, YUH-PAN CHEN, HONG-YEN HSU

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Keywords: Fritillaria, traditional Chinese medicine, 13, 17-didehydrocevanine alkaloid, 20-deoxy-5α-cevanine alkaloid, D/E trans-5α-cevanine alkaloid

JOURNAL FREE ACCESS

1988 Volume 36 Issue 11 Pages 4316-4329

DOI https://doi.org/10.1248/cpb.36.4316

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Abstract

A novel (22S, 25R)-13, 17-didehydro: 5α-cevanine alkaloid, ebeienine (1), was isolated from the bulbs of Fritillaria ebeiensis var.purpurea, together with (25S)-20-deoxy-5α-cevanin-3, β, 6β-diol (ebeiedine (2)), and (25S)-20-deoxy-5α-cevanin-3α-o1-6-one (ebeiedinone (3)). Their structures were elucidated by physical methods and finally confirmed by X-ray crystal structure determination.

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