ISOLATION OF BACILLUS STEAROTHERMOPHILUS CONSTITUENT THAT SUPPRESSES MOUSE MIXED LEUKOCYTE REACTION IN VITRO

Yasuhiro KOHAMA; Norihito MURAYAMA; Keishi TANAKA; Akira INADA; Tsutomu NAKANISHI; Masahiko ITOH; Xing YING; Tsutomu MIMURA

doi:10.1248/cpb.39.3378

小濱靖弘, 村山宣人, 田中啓詞, 稲田昭, 中西勤, 伊藤雅彦, 応星, 三村務

著者情報

キーワード: thermophile, Bacillus stearothermophilus, immunosuppressant, mixed leukocyte reaction, cyclosporin A, T cell proliferation

ジャーナルフリー

1991 年 39 巻 12 号 p. 3378-3380

DOI https://doi.org/10.1248/cpb.39.3378

詳細

抄録

A novel immunosuppressant, Fr.5-B, has been isolated from the debris of Bacillus stearothermophilus UK563 autolysate. Fr.5-B suppressed mouse mixed leukocyte reaction at doses ranging from 10^-4 to 1 μg/ml, but not proliferation stimulated by concanavalin A and lipopolysaccharide.

責任著者(Corresponding author)

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