Studies on the Constitutents of Veratrum Plants. II. Constituents of Veratrum nigrum L. var. ussuriense. (1). Structure and 1H-and 13C-Nuclear Magnetic Resonance Spectra of a New Alkaloid, Verussurinine, and Related Alkaloids

Weijie ZHAO; Yasuhiro TEZUKA; Tohru KIKUCHI; Jun CHEN; Yongtian GUO

doi:10.1248/cpb.39.549

Studies on the Constitutents of Veratrum Plants. II. Constituents of Veratrum nigrum L. var. ussuriense. (1). Structure and ¹H-and ¹³C-Nuclear Magnetic Resonance Spectra of a New Alkaloid, Verussurinine, and Related Alkaloids

趙偉傑, 手塚康弘, 菊池徹, 陳均, 郭永沺

著者情報

キーワード: Veratrum nigrum var. ussuriense, steroidal alkaloid, verussurinine, 15-O-(2-methylbutyroyl)germine, germidine, germerine, ^1H-NMR, ^<13>C-NMR, 2D NMR

ジャーナルフリー

1991 年 39 巻 3 号 p. 549-554

DOI https://doi.org/10.1248/cpb.39.549

詳細

抄録

Alkaloidal constituents of the roots and rhizoma of Veratrum nigrum L. var. ussuriense (Liliaceae), which are used as a source of the Chinese crude drug "Li-lu, " were examined and a new alkaloid named verussurinine and six known alkaloids have been isolated. The structure of verussurinine was determined to be 16-O-(2-methylbutyroyl)germine (1) by means of spectroscopic methods, and six other alkaloids were identified as germidine (2), germerine (3), 15-O-(2-methylbutyroyl)germine (4), verazine (5), jervine (6), and neogermbudine (7), Complete assignments of the proton and carbon-13 nuclear magnetic resonance (¹H- and ¹³C-NMR) signals of these alkaloids are also presented.

責任著者(Corresponding author)

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