Formation of Pyrazine Derivatives from D-Glucosamine and Their Deoxyribonucleic Acid (DNA) Strand Breakage Activity

Kunihiro SUMOTO; Michiko IRIE; Nobuko MIBU; Seiji MIYANO; Yukihiko NAKASHIMA; Kenji WATANABE; Tadatoshi YAMAGUCHI

doi:10.1248/cpb.39.792

須本國弘, 入江美智子, 壬生伸子, 宮野成二, 中島幸彦, 渡邊健治, 山口忠敏

著者情報

キーワード: pyrazine, fructosazine, deoxyfructosazine, DNA strand breakage, plasmid pBR322, D-glucosamine, L-cysteine, aminosugar, copper ion

ジャーナルフリー

1991 年 39 巻 3 号 p. 792-794

DOI https://doi.org/10.1248/cpb.39.792

詳細

抄録

Two pyrazine derivatives [fructosazine (3) and deoxyfructosazine (6)] were simultaneously formed in a solution of D-glucosamine hydrochloride under various conditions. They showed deoxyribonucleic acid (DNA) strand breakage activity in plasmid pBR322 comparable to that of D-glucosamine. The DNA strand breakage by fructosazine (3) was stimulated by Cu²⁺.

責任著者(Corresponding author)

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