Repandiol, a New Cytotoxic Diepoxide from the Mushrooms Hydnum repandum and H. repandum var. album

Akira TAKAHASHI; Takeshi ENDO; Shigeo NOZOE

doi:10.1248/cpb.40.3181

Akira TAKAHASHI, Takeshi ENDO, Shigeo NOZOE

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Keywords: cytotoxic diepoxide, repandiol, (2R, 3R, 8R, 9R)-4, 6-decadiyne-2, 3 : 8, 9-diepoxy-1, 10-diol, mushroom, basidiomycete, Hydnum repandum, Hydnum repandum var. album, structure elucidation, total synthesis

JOURNAL FREE ACCESS

1992 Volume 40 Issue 12 Pages 3181-3184

DOI https://doi.org/10.1248/cpb.40.3181

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Abstract

Repandiol, a new cytotoxic diepoxide has been isolated from the mushrooms Hydnum repandum and H. repandum var. album. The chemical structure was elucidated as (2R, 3R, 8R, 9R)-4, 6-decadiyne-2, 3 : 8, 9-diepoxy-1, 10-diol on the basis of spectroscopic analysis. The structure was confirmed by the synthesis of optically active repandiol. Repandiol displayed potent cytotoxic activity against various tumor cells.

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