Russuphelin A, a New Cytotoxic Substane from the Mushroom Russula subnigricans HONGO

Akira TAKAHASHI; Tsutomu AGATSUMA; Mamoru MATSUDA; Tomihisa OHTA; Tetsuji NUNOZAWA; Takeshi ENDO; Shigeo NOZOE

doi:10.1248/cpb.40.3185

Akira TAKAHASHI, Tsutomu AGATSUMA, Mamoru MATSUDA, Tomihisa OHTA, Tetsuji NUNOZAWA, Takeshi ENDO, Shigeo NOZOE

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Keywords: cytotoxic substance, russuphelin A, 2, 6-bis(2, 6-dichloro-4-hydroxyphenyloxy)-1, 4-dimethoxybenzene, basidiomycete, mushroon, Russula subnigricans, strucutre elucidation, total synthesis

JOURNAL FREE ACCESS

1992 Volume 40 Issue 12 Pages 3185-3188

DOI https://doi.org/10.1248/cpb.40.3185

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Abstract

A new cytotoxic substance, designated russuphelin A (1), has been isolated from the mushroom Russula subnigricans HONGO(Basidiomycetes). The structure was elucidated as 2, 6-bis(2, 6-dichloro-4-hydroxyphenyloxy)-1, 4-dimethoxy-benzene on the basis of spectroscopic data and confirmed by total synthesis.

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