6-GINGESULFONIC ACID, A NEW ANTI-ULCER PRINCIPLE, AND GINGERGLYCOLIPIDS A, B AND C, THREE NEW MONOACYLDIGALACTOSYLGLYCEROLS, FROM ZINGIBERIS RHIZOMA ORIGINATING IN TAIWAN

Abstract

By monitoring the effects on HCI / ethanol-induced gastric lesions in rats, a new anti-ulcer principle named 6-gingesulfonic acid was isolated from Zingiberis Rhizoma, the dried rhizome of Zingiber officinale ROSCOE (cultivated and processed in Taiwan) together with three new monoacyldigalactosylglycerols named gingerglycolipids A, B and C. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. 6-Gingesulfonic acid showed more potent anti-ulcer activity than 6-gingerol and 6-shogaol.