RAPID INCREASE OF INOSITOL 1, 4, 5-TRISPHOSPHATE CONTENT IN ISOLATED RAT ADIPOSE TISSUE BY VANADATE

Tetsuo MORITA; Toshio MOTOYASHIKI; Yasuyuki TSURUZONO; Asako KANAGAWA; Nobuaki TOMINAGA; Hiroshi UEKI

doi:10.1248/cpb.40.2242

Tetsuo MORITA, Toshio MOTOYASHIKI, Yasuyuki TSURUZONO, Asako KANAGAWA, Nobuaki TOMINAGA, Hiroshi UEKI

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Keywords: inositol 1, 4, 5-trisphosphate, vanadata, Ca²⁺ release, adipose tissue

JOURNAL FREE ACCESS

1992 Volume 40 Issue 8 Pages 2242-2244

DOI https://doi.org/10.1248/cpb.40.2242

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Abstract

Sodium orthovanadate increased inositol 1, 4, 5-trisphosphate content in rat adipose tissue in a time-dependent manner up to 30 s; its maximal effect was two-fold higher than the basal level of IP₃, and it probably consequently causes elevation of the intracellular Ca²⁺.

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