Chirality of the 3-Hydroxy-3-methylglutaric Acid Moiety of Fasciculic Acid A, a Calmodulin Antagonist Isolated from Naematoloma fasciculare

Shigeo NOZOE; Akira TAKAHASHI; Tomihisa OHTA

doi:10.1248/cpb.41.1738

Shigeo NOZOE, Akira TAKAHASHI, Tomihisa OHTA

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Keywords: fasciculic acid A, 3-hydroxy-3-methylglutaric acid, chirality, Naematoloma fasciculare, mushroom

JOURNAL FREE ACCESS

1993 Volume 41 Issue 10 Pages 1738-1742

DOI https://doi.org/10.1248/cpb.41.1738

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Abstract

The chirality of the 3-hydroxy-3-methylglutaric acid (HMGA) moiety of fasciculic acid A (1), a calmodulin antagonist isolated from Naematoloma fasciculare, was established to be S by comparing the ¹H-NMR spectrum of the L-alanylamide of HMGA derived from 1 with those of its diastereomer and the diastereomeric mixture.

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