Synthesis of the Metabolites of Clentiazem

Hirozumi INOUE; Susumu NAKAMURA; Hisao OTSUKA; Mitsunori GAINO; Tsunehiro HARADA; Kenji MATSUKI; Mikio TAKEDA

doi:10.1248/cpb.42.167

Hirozumi INOUE, Susumu NAKAMURA, Hisao OTSUKA, Mitsunori GAINO, Tsunehiro HARADA, Kenji MATSUKI, Mikio TAKEDA

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Keywords: metabolite, basic metabolite, acidic metabolite, neutral metabolite synthesis, clentiazem

JOURNAL FREE ACCESS

1994 Volume 42 Issue 1 Pages 167-172

DOI https://doi.org/10.1248/cpb.42.167

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Abstract

The metabolites of clentiazem in the urine or bile of rats and dogs were investgated. Fifteen basic, 6 acidic, 2 neutral and 4 conjugated metabolites were isolated. In the present paper, fourteen reference compounds as shown in Charts, 1, 2 and 3 were synthesized to identify the structures of the metabolites in procedures fundamentally similar to those empolyed in the synthesis of the corresponding metabolites of diltiazem.

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