NEW CHLORINE-CONTAINING PRENYLATED C6-C3 COMPOUNDS INCREASING CHOLINE ACETYLTRANSFERASE (ChAT) ACTIVITY IN CULTURE OF POSTNATAL RAT SEPTAL NEURONS FROM ILLICIUM TASHIROI

Yoshiyasu FUKUYAMA; Kazumi OKAMOTO; Youko KUBO; Naomi SHIDA; Mitsuaki KODAMA

doi:10.1248/cpb.42.2199

NEW CHLORINE-CONTAINING PRENYLATED C₆-C₃ COMPOUNDS INCREASING CHOLINE ACETYLTRANSFERASE (ChAT) ACTIVITY IN CULTURE OF POSTNATAL RAT SEPTAL NEURONS FROM ILLICIUM TASHIROI

Yoshiyasu FUKUYAMA, Kazumi OKAMOTO, Youko KUBO, Naomi SHIDA, Mitsuaki KODAMA

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Keywords: Illicium tashiroi, Magnoliaceae, 2(R)-12-chloro-2, 3-dihydroillicinone E, 12-chloroillicinone E, prenylated C₆-C₃ compound, choline acetyltransferase activity

JOURNAL FREE ACCESS

1994 Volume 42 Issue 10 Pages 2199-2201

DOI https://doi.org/10.1248/cpb.42.2199

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Abstract

The structures of two new chlorine-containing C₆-C₃ compounds isolated from the woods of Illicium tashiroi have been established as 2(R)-12-chloro-2, 3-dihydroillicinone E (1) and 12-chloroillicinone E (2) by X-ray crystallographic analysis and spectroscopic data, respectively. Compound 1 has been found to significantly increase ChAT activity in culture of P10 rat sepatl neurons.

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