Synthesis, Lipophilicity Studies and Antibacterial Properties of Some Novel Quaternary Ammonium Salts

Theodora SIATRA-PAPASTAIKOUDI; Aspasia PAPADAKI-VALIRAKI; Anna TSANTILI-KAKOULIDOU; Leonidas TZOUVELEKIS; Andreas MENTIS

doi:10.1248/cpb.42.392

Theodora SIATRA-PAPASTAIKOUDI, Aspasia PAPADAKI-VALIRAKI, Anna TSANTILI-KAKOULIDOU, Leonidas TZOUVELEKIS, Andreas MENTIS

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Keywords: quaternary ammonium salt, 15-phenyl-pentadecanoic acid, antibacterial activity, lipophilicity, thin layer chromatography, hydrophobic fragmental constant

JOURNAL FREE ACCESS

1994 Volume 42 Issue 2 Pages 392-394

DOI https://doi.org/10.1248/cpb.42.392

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Abstract

The synthesis of some novel quaternary ammonium salts, derivatives of 15-phenyl-decapentanoic acid, is described. Their lipophilicity was estimated applying the Hansch-Leo fragmental procedure and measured by means of reversed phase thin layer chromatography. All compounds were tested for their antibacterial activity against Gram positive and gram negative microorganisims. The less lipophilic compounds showed weak activity, mainly against gram positive microorganisms.

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