Large Laboratory Scale Synthesis of (2S, 3S)-2-(4-Methoxybenzyloxy)-3, 4-O-(3-pentylidene)-1, 3, 4-butantriol, a Versatile Chiral Building Block in Natural Product Synthesis

Abstract

(2S, 3S)-2-(4-Methoxybenzyloxy)-3, 4-O-(3-pentylidene)-1, 3, 4-butanetriol (3), a versatile chiral building block for an essential structural unit of complex natural products, was synthesized starting from dimethyl L-(+)-tartrate (5) on both a small scale and a large scale in good yield.