Inhibitory Effects of a Novel Water-Soluble Cyclophane on the Hydrolysis Reactions of Aromatic Esters

Muneharu MIYAKE; Yasuo FUJIMOTO

doi:10.1248/cpb.42.1938

Muneharu MIYAKE, Yasuo FUJIMOTO

Author information

Keywords: water-soluble cyclophane, hydrolysis, aromatic ester, inhibitory effect, Lineweaver-Burk type plot

JOURNAL FREE ACCESS

1994 Volume 42 Issue 9 Pages 1938-1939

DOI https://doi.org/10.1248/cpb.42.1938

Details

Abstract

The effects of a novel water-soluble cyclophane (TGCP 44, 1) on the hydrolysis reactions of aromatic esters have been studied. TGCP 44(1) was found to inhibit the hydrolysis of three aromatic esters, p-nitrophenyl chloroacetate (2), glycine p-nitrophenyl ester hydrobromide (3) and 1-nitro-2-naphthyl chloroacetate (4). The hydrolysis rates of the aromatic esters were retarded by 3.8-7.65 fold relative to the spontaneous rates.

Corresponding author

Register with J-STAGE for free!