Structures of Six New Eremophilenolides from the Rhizomes of Petasites japonicus MAXIM,

Abstract

Six new eremophilenolides, 3β-hydroxyeremophil-7(11)-en-12, 8β-olide (1), 3β-hydroxy-6β-methoxyeremophil-7(11)-en-12, 8β-olide (2), 3β-hydroxy-6β, 8α-dimethoxyeremophil-7(11)-en-12, 8β-olide (3), the mixture of 3β, 8α-dihydroxy-6β-tigloyloxyeremophil-7(11)-en-12, 8β-olide (4) and 3β, 8β-dihydroxy-6β-tigloyloxyeremophil-7(11)-en-12, 8α-olide (5), and 6β-angeloyloxy-8β-hydroxy-3-oxoeremophil-7(11)-en-12, 8α-olide (6), were isolated from the dried rhizomes of Petasites japonicus MAXIM. (Compositae). The structures of these compounds were elucidated on the basis of spectroscopic evidence.