ASYMMETRIC SYNTHESIS OF (S)-(+)-AND (R)-(-)-NZ-105 THROUGH THE MODIFIED MICHAELIS-ARBUZOV REARRANGEMENT AS A KEY STEP

Tatsuhisa KATO; Mamiko TEJIMA; Hirosato EBIIKE; Kazuo ACHIWA

doi:10.1248/cpb.44.1132

Tatsuhisa KATO, Mamiko TEJIMA, Hirosato EBIIKE, Kazuo ACHIWA

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Keywords: 1, 4-dihydropyridine, calcium antagonist, NZ-105, Hunsdiecker reaction, Michaelis-Arbuzov reaction

JOURNAL FREE ACCESS

1996 Volume 44 Issue 5 Pages 1132-1134

DOI https://doi.org/10.1248/cpb.44.1132

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Abstract

The asymmetric synthesis of the (S)-(+)- and (R)-(-)-NZ-105 from the prochiral compound (1) was realized by using the modified Hunsdiecker reaction followed by the modified Michaelis-Arbuzov reaction with zerovalent palladium.

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