A CONVENIENT SYNTHESIS OF BENZO[C]PHENANTHRIDINE ALKALOID, CHELERYTHRINE, BY THE PALLADIUM-ASSISTED INTERNAL BIARYL COUPLING REACTION

Takashi HARAYAMA; Toshihiko AKIYAMA; Kazuko KAWANO

doi:10.1248/cpb.44.1634

Takashi HARAYAMA, Toshihiko AKIYAMA, Kazuko KAWANO

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Keywords: internal biaryl coupling, Heck type reaction, halo-amide, benz[c]phenanthridine alkaloid, chelerythrine

JOURNAL FREE ACCESS

1996 Volume 44 Issue 8 Pages 1634-1636

DOI https://doi.org/10.1248/cpb.44.1634

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Abstract

Total synthesis of chelerythrine, a benzo[c]phenanthridine alkaloid, was accomplished via the internal aryl-aryl coupling reaction of halo-amide (4) by the palladium-assisted cyclization reaction.

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