Metabolism of Drugs. XVIII. : The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3, 5-dimethylbarbituric Acid). (8). : The Quantitative Determination of Main Biotransformation Products of Methylhexabital in the Urine of Rabbits by Ultraviolet Spectrophotometry.

Abstract

Method of simultaneous determination of three main metabolites of MHB in urine by paper chromatography in conjunction with ultraviolet spectrophotometry was described. Approximately 25.7% of MHB administered was converted to 3-keto-nor-MHB (4.9%), 3-keto-MHB (4.5%), and 3-OH-MHB (16.3%), and excreted in amounts independent of the dosage administered.