Studies on Mycolic Acid and Related Compounds. III. Synthesis of α-Mycolic Acid found in Brevannes Strain of Human-type Tubercle Bacilli (1).

Abstract

Condensation of 2-tetracosyl-3-acetoxyoctacosanoic acid chloride and ethyl benzyl tetracosylmalonate afforded ethyl 2, 4-ditetracosyl-3-oxo-5-acetoxytriacontanoate whose reduction with sodium borohydride gave 2, 4-ditetracosyl-3, 5-dihydroxytriacontanoic acid. Preparation of their derivatives was examined.