Studies on Pyrone Derivatives. VI. On the Reaction between Dehydroacetic Acid and Several Ammonium Salts in Solution

Abstract

It was found that dehydroacetic acid or its sodium salt reacted in the solution with not only ammonia but with various organic and inorganic ammonium salts under extremely mild condition and formed its imide, 3-(1-iminoethyl)-4-hudroxy-6-methyl-2-pyrone (DHA-imide). Dehydroacetic acid and its sodium salt are known to have low toxicity and examinations were made to see if a similar reaction would occur in vivo when dehydroacetic acid is administered. In a preliminary test with a dog with Eck's fistula, administration of sodium dehydroacetate in hyper-ammonemia was effective to a certain extent in reducing the value of blood ammonia.