Studies on Carcinostatic Substances. XXIII. Correlation between Anti-tumor and leucopenia-inducing Effects of Alkylating Agents

Abstract

Each of 10 different derivatives of nitrogen mustard was tested on 12 Yoshida sarcoma rats for their life-prolongation and leucopenia-inducing effects. It was found that some showed a very strong effect of life-prolongation on the tumor rats, although the leucopenia-inducing effect of such compounds was quite equal to those of other compounds.