Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Organization of non-centrosomal microtubules in epithelial cells
Mika ToyaMasatoshi Takeichi
著者情報
ジャーナル フリー 早期公開

論文ID: 16015

この記事には本公開記事があります。
詳細
抄録
Polarized epithelial cells contain a characteristic array of microtubules in which non-centrosomal microtubules are aligned along the apical-to-basal axis of the cell with their minus ends oriented towards the apical pole. Although this unique orientation of microtubules was discovered in the late 1980s, how this orientation is established remains unresolved partly because of limited information about molecular factors that regulate the minus ends of non-centrosomal microtubules. Recent studies, however, identified novel minus end–associated proteins, revealing mechanisms by which the polarized arrays of microtubules are established in epithelial cells. These studies have also demonstrated the importance of apico-basally orientated microtubules in intra-structural organization of cells. This review focuses on recent progress of our understanding of the molecular basis for epithelium-specific microtubule assembly and function.
著者関連情報
© 2016 by Japan Society for Cell Biology
feedback
Top