抄録
Biodegradable microspheres containing cisplatin were prepared by a solvent-evaporation method and release profiles were evaluated in vitro. Cisplatin was entrapped in the microspheres prepared by poly (L-lactic acid) (L-PLA)with high encapsulation efficiency of about 80%. The microspheres containing cisplatin were spherical with diameters of about 60 μm. About 20% of the loaded cisplatin was released during the initial hours and release rates of cisplatin were very small thereafter. Attempts were made to enhance the release rate by incorporating fatty acid esters or gelatin as additives in the microspheres. The release patterns of cisplatin from the microspheres were different depending on the kinds of esters. In order to clarify the causes of its difference, appearances of the microspheres were observed with a scanning electron microscope. There was difference in their appearances in their surface and crosssection. The release rates of cisplatin from the microspheres were increased by incorporating gelatin in them.
