Immunization with ACE (Angiotensin Converting Enzyme) Develops Diabetic Changes in the Kidney and Retina in Diabetogenic Rats

Seikoh NISHIDA; Tamaki SASAKI; Hisashi KIMURA; Junji TANAKA; Tsutomu NOHNO; Yasushi HIROKAWA; Michihiro MATSUKI; Kiyoshi ICHIHARA

doi:10.1507/endocrj.50.801

NOTES

Immunization with ACE (Angiotensin Converting Enzyme) Develops Diabetic Changes in the Kidney and Retina in Diabetogenic Rats

Seikoh NISHIDA, Tamaki SASAKI, Hisashi KIMURA, Junji TANAKA, Tsutomu NOHNO, Yasushi HIROKAWA, Michihiro MATSUKI, Kiyoshi ICHIHARA

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Keywords: Immunization with rabbit lung ACE, Retinal change, Glomerular change, Rabbits and rats

JOURNAL FREE ACCESS

2003 Volume 50 Issue 6 Pages 801-807

DOI https://doi.org/10.1507/endocrj.50.801

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Abstract

In normal New Zealand white rabbits, immunization with rabbit lung ACE (angiotensin converting enzyme) induced atherosclerotic retinal changes, and glomerular changes similar to those seen in diabetic nephropathy. Also, in genetically diabetogenic rats, immunization with the rabbit lung ACE induced diabetic nephropathy and retinopathy.

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