Sulfonamide諸誘導体の薬理学的研究 III. Homosulfamine並にその誘導体の毒性

抄録

Toxicological examinations with a series of samples of homosulfamine (marfanil) and its derivatives, which were prepared during the war in this country, revealed that they were all depressant and paralytic to mice. LD50 of homosulfamine administered orally, subcutaneously and. intravenously were 3.0 g, 3.5 g and 2.17 g/kg respectively. As for its three derivatives, LDSO by mouth were 7.9 g/kg with di-homosulfamine, 18.3 g/kg with homosulfapyridine and 4.5 g/kg with dimethylhomosulfamine, and when given intraperitoneally, they were 0.57 g, 0.75 g, and 0.75 g/kg with respective compounds. Kymographic examinations carried out in rabbits with homosulfamine were indicative of its comparatively high toxicity resulting in a. respiratory failure. With isolated heart-preparations of frog and toad, the cardiac function was depressed when administered in a large dose, and with some vessel-preparations of bull-frog and rabbit, the circulatory outflow through them was also temporarily disturbed.