Food Science and Technology Research
Online ISSN : 1881-3984
Print ISSN : 1344-6606
ISSN-L : 1344-6606
Original papers
High Oleic Peanut Oil Modulates Promotion Stage in Lung Tumorigenesis of Mice Treated with Methyl Nitrosourea
Tatsuya YAMAKIIsao NAGAMINEKeiko FUKUMOTOTomohiro YANOMitsuyoshi MIYAHARAHidetoshi SAKURAI
著者情報
ジャーナル オープンアクセス

2005 年 11 巻 2 号 p. 231-235

詳細
抄録
This study was undertaken to estimate the effect of high-oleic peanut oil (HO) on the promotion stage of lung tumorigenesis in mice. On day 30 after methyl nitrosourea administration, dietary HO inhibited ornithine decarboxylase activity, induced the inactivation of Mek, and reduced the level of proliferating cell nuclear antigen in lungs of mice more than did high-linoleic safflower oil. A parallel effect was observed in the level of prostaglandin E2 in the lungs. These results suggest that HO suppresses the promotion stage of lung tumorigenesis in mice and that the suppression correlates to the level of PGE2.
著者関連情報
© 2005 by Japanese Society for Food Science and Technology

This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
https://creativecommons.org/licenses/by-nc-sa/4.0/
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