Food Science and Technology Research
Online ISSN : 1881-3984
Print ISSN : 1344-6606
ISSN-L : 1344-6606
Original papers
Optimization Extraction Conditions with Ultrasound for Anti-hyperglycemic Activities from Psidium guajava Leaf
Ching-Wen LiuYi-Cheng WangChang-Yi HuangHsi-Chi LuWen-Dee Chiang
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2015 年 21 巻 4 号 p. 615-621

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The present study evaluated the optimal parameters for Psidium guajava leaf extraction by ultrasound to obtain maximal anti-hyperglycemic activities in the extract. The response surface methodology was employed for empirical model building. The maximum inhibition of the two starch-digesting enzymes α-amylase and α-glucosidase was determined. The optimized extraction parameters of solvent-to-solid ratio, extraction time, and extraction temperature for obtaining the maximum inhibitory activity for 50 µg/mL extract were determined to be the following: 12.07 (v/w), 5.22 min, and 59.77°C for α-amylase (47.23% ± 0.76%) and 12 (v/w), 5.22 min, and 59.94°C for α-glucosidase (59.42% ± 0.65%), respectively. The F values for the lack-of-fit were not significant (p > 0.05) for both second-order models, indicating them to be appropriate for describing the response surface. In conclusion, our study presents the optimal conditions for ultrasound-assisted extraction of guava leaf as a potential substance for use in diabetes treatment.
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© 2015 by Japanese Society for Food Science and Technology

This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
https://creativecommons.org/licenses/by-nc-sa/4.0/
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