2018 Volume 24 Issue 1 Pages 119-127
Previously, we reported that 4-week enzymatically synthesized glycogen (ESG) supplementation reduced lipid accumulation in diet-induced obese rats. The aim of this study was to investigate the effects of long-term dietary ESG supplementation on lipid metabolism of diet-induced obese mice. Male C57BL/6NCr mice were fed a control or a high-fat diet containing 0%, 10%, or 20% ESG for 15 weeks. In the high-fat diet groups, ESG showed significant suppressive effect on adipose tissue weight. Supplementation of ESG decreased plasma cholesterol and liver lipid levels. Although, ESG substantially increased fecal lipid, ESG did not affect lipid metabolism related gene expression. In control groups ESG increased body temperature and plasma NO, although the effects were not observed in high-fat groups. In the test of single administration, ESG significantly suppressed lipid absorption. In this study, we confirmed the anti-obese effect of ESG. It is mainly due to inhibition of lipid absorption by ESG.