Protective Effects of Tyrosol Against Oxidative Damage in L6 Muscle Cells

Abstract

Tyrosol (2-(4-hydroxyphenyl) ethanol) is a phenylethanoid present in olive oil, with anti-oxidative, anti-inflammatory, and cerebroneural protection effects. In this study, the protective effect of tyrosol against oxidative damage was measured in L6 muscle cells. Tyrosol effectively inhibited H₂O₂-induced L6 cell death in part through regulation of ERK, JNK, and p38 MAP kinase and increased ATP production. In addition, it increased HO-1 expression in the cell. Based on results, tyrosol is effective in inhibiting oxidative damage of muscle cells.