Screening of Phosphate-accumulating Probiotics for Potential Use in Chronic Kidney Disorder

Abstract

Hyperphosphatemia is a secondary health issue that arises during chronic kidney disorder (CKD). Phosphate binders and dialysis are prescribed in later stages of CKD, although they may lead to harmful side-effects and worsen quality of life. Therefore, we examined the potential of intestinal bacteria (lactic acid bacteria and bifidobacteria) as phosphate-accumulating organisms (PAOs), whether PAO-formulated food can prevent CKD at earlier stages. Among the experimental organisms, Bifidobacterium adolescentis JCM1275 was the most effective. The effects of prebiotic and soy peptides were also evaluated where fructo-oligosaccharide was found to further enhance phosphate accumulation by B. adolescentis JCM1275, resulting in the best phosphate accumulation activity, identified in the study. Therefore, certain bifidobacteria and lactic acid bacteria strains have the potential to act as biological phosphate accumulators and contribute to the prevention of CKD pathology and improve patient outcome by care (not cure by medicines).