Toxic Effects of Furosine by Oral Intake on Liver and Kidney and Toxicokinetics Research in Mice Acute Toxicity Model

Abstract

In the acute toxicity model, 30 mice were randomly divided into 6 groups, control (without any treatment) and furosine-treated groups (4 h and 12 h group), by both orally administeration and tail vein injection. Furosine with the dosage of 0.24 g/kg body weight (b.w.) was administrated into the mice, and the liver and kidney tissue were dissected out. Organ index and biochemical indicators were obtained, and the concentration of furosine in liver and kidney tissue was quantified. Comparing with the control, furosine caused significant changes of biochemical indicators in liver and kidney tissue in 4 h and 12 h groups. This study for the first time provided evidences that furosine with the dosage of 0.24 g/kg posed acute adverse biological effects on the health of animals, and suggested that liver and kidney were the toxicity target organs.